منابع مشابه
Cytokines and STATs in Liver Fibrosis
Liver fibrosis, or cirrhosis, is a common end-stage condition of many chronic liver diseases after incomplete recovery from hepatocyte damage. During fibrosis progression, hepatocellular damage and inflammation trigger complex cellular events that result in collagen deposition and the disruption of the normal liver architecture. Hepatic stellate cell activation and transdifferentiation into myo...
متن کاملAnimal Models Of Liver Cirrhosis And Fibrosis
Animal modeling is a crucial necessity in clinical studies of liver diseases. Authenticity of the data which are produced using this tool under different conditions and accuracy of the analyses and assessments which would be based on such data sets is completely dependent on the adoption of a standardized methodology for analyzes and assessment of these data sets. Cirrhosis and Fibrosis are amo...
متن کاملCytokines and pulmonary fibrosis.
Chronically inflamed and fibrotic tissue of the respiratory tract can be shown to actively express the genes and products of a number of powerful growth and differentiating factors. The initial activation of lung inflammatory cells, including alveolar macrophages, is presumed to result in the release of early acting cytokines such as IL-1 and TNF. Subsequent activation and possible phenotype al...
متن کاملCytokines, STATs and liver disease.
The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathway, activated by more than 50 cytokines or growth factors, plays critical roles in a wide variety of cellular functions in the hematopoietic, immune, neuronal and hepatic systems. In the liver, this signaling pathway, activated by more than 20 cytokines, growth factors, hormones, and hepatitis viral pr...
متن کاملLiver inflammation and fibrosis
Introduction Chronic liver inflammation leads to liver cirrhosis, which is the 12th leading cause of death in the US (1), accounting for 32,000 deaths in the US and more than 1 million deaths each year worldwide (2). Chronic pathologic processes include viral infection, alcoholic liver disease, nonalcoholic steatohepatitis (NASH), and autoimmune diseases. Depending on the type of underlying liv...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 2000
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.23.611